| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_25f5e60cca882cd756ee1cd36c3fef16 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-16 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C403-20 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C403-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C403-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 |
| filingDate |
1994-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e39acd816f65109902eca617c0096695 |
| publicationDate |
1995-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9503274-A1 |
| titleOfInvention |
Process for the preparation of n-(4-hydroxyphenyl)-retinamide |
| abstract |
This invention is directed to an efficient, mild, high yield process for the large scale synthesis of N-(4-hydroxyphenyl)-retinamide comprising the preferred steps of reacting retinoic acid with dimethylchloroformamidinium chloride to form retinoyl chloride which in turn is reacted with bis-(N, O)-trimethylsilyl-p-aminophenol to eventually form N-(4-hydroxyphenyl)-retinamide and to the novel use of bis-(N, O)-trimethylsilyl-p-aminophenol to eventually form a hydroxyphenylamide, particularly N-(4-hydroxyphenyl)-retinamide and methods of recrystallizing N-(4-hydroxyphenyl)-retinamide to obtain the stable 'A' polymorph thereof. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9950240-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100392339-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6310247-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0035856-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102260186-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102260186-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8002883-B2 |
| priorityDate |
1993-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |