http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9501365-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f263177549abb86bdd90d541968fca12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_19cd947754fc1a8a9835bbf5afe2056d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-682 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6813 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-682 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G81-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6813 |
| filingDate | 1994-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_444b91872915e9bf9ae2fd6bff18d361 |
| publicationDate | 1995-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9501365-A1 |
| titleOfInvention | Synthesis of branched nucleic acids |
| abstract | The invention provides methods and compositions for convergent synthesis of branched polymers useful as molecular probes. The invention also includes several novel branched polymeric structures particularly useful for detecting target polynucleotides. Branched polymers of the invention comprise at least two branches: at least one branch is a target binding moiety capable of specifically binding to a target molecule of interest and one or more branches are signal generation moieties capable of directly or indirectly generating a detectable signal. In accordance with the method of the invention branched polymers are assembled from components having phosphorothioate groups and/or haloacyl- or haloalkylamino groups. The phosphorothioate and haloacyl- or haloalkylamino groups react rapidly and efficiently when brought into contact to form thiophosphorylacyl- or thiophosphorylalkylamino bridges which complete the assembly of a branched polymer. The method of the invention permits thorough purification and isolation of the components prior to final assembly. Incomplete branched polymers are readily separated from the desired product by standard means. The method of the invention permits the synthesis of several novel branched polymer configurations. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6303376-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1992634-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11166976-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5962426-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9713874-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6214549-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6503714-B1 |
| priorityDate | 1993-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 188.