| abstract |
A dopamine (DA) reincorporation inhibitor containing a compound represented by general formula (1) or a physiologically acceptable salt thereof as the active ingredient, wherein R?1 and R2¿ represent each hydrogen or halogen; R3 represents hydrogen, alkyl or acyl; R4 represents hydrogen, alkyl, acyl, alkylsulfonyl or optionally esterified carboxyl; Ar represents optionally substituted phenyl or a nitrogenous monocyclic heteroaromatic group; m represents a number of 1 to 5; and n represents a number of 0 to 5. This inhibitor does not produce any side effect, is safe, has potent activities of inhibiting DA reincorporation and enhancing autonomic movement, and is very useful for treating Parkinson's syndrome believed to be a disease caused by DA deficiency. |