| abstract |
The use of sucrose octasulfate compounds to prepare interferons is disclosed. Addition of sucrose octasulfate to interferon-containing solutions results in precipitation of interferons as substantially water-insoluble adducts that retain interferon activity, thereby effecting separation and/or purification of the interferons. The adducts are highly stable and, as sucrose octasulfates are not metabolized in vivo, the adducts can be used directly as pharmaceutical compositions for the treatment of, for example, infectious disease, inflammatory disease, neoplastic and proliferative disorders. |