| abstract |
Piperidine derivatives of formula (I) wherein n and m independently are 0, 1, 2, or 3; A is cycloalkylene or cycloalkylidenes; X is O or NH; Y is O, S, NH, NCN, or N-lower alkyl; R1 is 1,2-benzisoxazol-3-yl, 1H-indazol-3-yl, or 1-methyl-1H-indazol-3-yl, all of which may be substituted; R2 is H or alkyl; and R3 is phenyl optionally substituted, or R3 is (a) wherein Z together with the double bond in the phenyl ring represents a 5- or 6-membered heterocyclic ring; or R?2 and R3¿ together with the nitrogen atom form a fused heterocyclic ring system; or pharmaceutically acceptable salts thereof are useful in the treatment of indications related to the CNS-system, cardiovascular system or to gastrointestinal disorders. |