| abstract |
The invention concerns anti-infective agents, such as antimicrobial agents, based on polyhexamethylene biguanide with a mean molecular weight Mw of 2,900 to 15,000, preferably 3,000 to 8,000, in particular 3,200 to 5,000, the anti-infective agents being used preferably in the form of an injury antiseptic and/or injury-treatment agent or as an antimicrobial, antiviral and/or antiparasitic agent, preferably by intravenous administration. A suitable concentration at which the polyhexamethylene biguanide can be used as an injury antiseptic and/or injury-treatment agent is 0.001 to 0.05 % by wt., in particular 0.005 to 0.012 % by wt. Compared with prior art disinfectants based on polyhexamethylene biguanide and used as injury antiseptics and injury-treatment agents, the polyhexamethylene biguanide proposed by the invention has a higher mean molecular weight Mw and exhibits an enhanced microbicidal action and, simultaneously, lower toxicity, as well as being free of side-effects on the central nervous system. |