http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9424081-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C41-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C41-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C41-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-225 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C43-205 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C47-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-56 |
| filingDate | 1994-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5118fbc3908bf4dce418aa6f906eaaa4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1bfa8d27abb51fa81b8069da5ccd8639 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8d55d52d3b027a3618ee8ea1bb417a1 |
| publicationDate | 1994-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9424081-A1 |
| titleOfInvention | Formylation process for aromatic aldehydes |
| abstract | A novel two-step reaction process for preparing 5-substituted-2-methoxybenzaldehyde compounds is disclosed wherein the substituent group is either isopropyl or trifluoromethoxy. The process involves (1) reacting a corresponding 4-substituted phenol compound with dimethyl carbonate in the presence of a tertiary-amine base to form the corresponding 4-substituted anisole compound, and (2) thereafter subjecting the latter intermediate product obtained in the first step to aromatic C-formylation on the ring with hexamethylenetetramine in the presence of trifluoroacetic acid, followed by hydrolysis, to ultimately yield the desired aldehyde compound. The two aromatic aldehyde compounds so obtained, viz., 2-methoxy-5-trifluoromethoxybenzaldehyde and 2-methoxy-5-isopropylbenzaldehyde, are known to be useful as intermediates that specifically lead to (2S^_,3S^_)-c^_i^_s^_-3-(2-methoxy-5-trifluoromethoxybenzyl)amino-2-phenylpiperidine and (2S^_,3S^_)-c^_i^_s^_-2-(diphenylmethyl)-N-[(2-methoxy-5-isopropylphenyl)methyl]-1-azabicyclo[2.2.2.]octane-3-amine, respectively. The latter final products, in turn, are both known to be useful in the field of medicinal chemistry as substance P receptor antagonists. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CZ-299029-B6 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1428814-A1 |
| priorityDate | 1993-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.