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filingDate 1994-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0067f8d790989a57cd4733e2d1ee9cbe
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publicationDate 1994-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-9423703-A1
titleOfInvention Manufacturing matrices
abstract The present invention is directed to a process for the manufacture of porous cellulose matrices with a defined particle size and a significantly higher porosity (i.e. pore volume) than conventional formulations, such as pellet formulations containing cellulose and binders. The process is applicable on a wide variety of substantially dry cellulose raw materials. The cellulose is mechanically treated with low adhesion to the process equipment during a controlled gradual addition of an aqueous based fluid, optionally containing a surface-active ingredient, into regular particles, which are finally dried to obtain dry porous cellulose matrices. The so obtained matrices can be used as carriers for bioactive substances in multiple-unit preparations or tablets.
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