| abstract |
Staple and semi-staple oligonucleotides useful as anti-sense molecules in cosmetics, diagnosis and especially pharmacology, and methods of preparation of such molecules. The staple and semi-staple oligonucleotides of the present invention are oligonucleotide type molecules, the 3' terminal or the two 3' and 5' terminals being engaged in intramolecular hydrogen bindings between pairs of complementary bases. As a result,these molecules are better able to withstand exonuclease attacks and act with greater durability as an anti-sense factor than the corresponding nuclear oligonucleotides. |