| abstract |
The present invention provides novel N-hydroxyurea and hydroxamic acid derivatives of chemical formula (I), wherein R is C1-C4 alkyl or -NR?1R2; R1 and R2¿ are each, independently, hydrogen or C¿1?-C4 alkyl; M is hydrogen or pharmaceutically acceptable cation; p and q are independently integers of two or three, the substituent A is optionally substituted phenyl, furyl, or thienyl, wherein the substituents are each, independently, halogen, C1-C6 alkyl, C1-C6 alkoxy, phenoxy or mono-substituted phenoxy, wherein the substituent in the substituted phenoxy is halogen, C1-C4 alkyl, C1-C4 alkoxy or halosubstituted alkyl; and the substituent A may be attached at any available positions on the spiro-ring. These compounds are useful for treatment or alleviation of inflammatory diseases, allergy and cardiovascular diseases in mammals and as the active ingredient in pharmaceutical compositions for treating such conditions. |