| abstract |
A novel type of formulation for the topical administration of antigens and/or vaccines to mammals via mucosal membranes comprising one or more adjuvants/vehicles selected from (a) polyoxyethylene sorbitan monoesters, (b) polyoxyethylene castor oil, (c) caprylic/capric acid glycerides and (d) gangliosides in an amount of 0.01 to 15 % (v/v) calculated on the total volume of the preparation. This formulation enhances the immunological response in a mammal following mucosal administration, e.g. nasal, oral, rectal or vaginal application. |