| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0c4322cb4de342be2dbedcbe0c278f6f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18d92c46f60af8af24e262b67381d7eb |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-715
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 |
| filingDate |
1994-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_879504d94ee1f2a6c5b34a7a114f0e37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f9d5fbb4d27c4197ebfc7f0084e25c1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_71f540a19b89662d3255b20c874f1421 |
| publicationDate |
1994-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9416684-A1 |
| titleOfInvention |
INHIBITION OF βARK AND β-ARRESTIN |
| abstract |
β-adrenergic receptor kinase (βARK) and β-arrestin function in the homologous or agonist-activated desensitization of G-protein coupled receptors. Both βARK-2 and β-arrestin-2 isoforms are highly enriched in and localized to the cilia and dendritic knobs of the olfactory receptor neurons where the initial events of olfactory signal transduction occur as well as being localized to spermatids. Administration of neutralizing antibodies to βARK-2 and β-arrestin-2 enhances the response to odorants and attenuates desensitization. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6110693-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6159707-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5891646-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014356342-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7018812-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7163800-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7214496-B2 |
| priorityDate |
1993-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |