http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9414803-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0dd0aaf6683e76e80eed2b852156c649 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff9920cc3ad60ccc16c8f50162dc6e5c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba045776bcd32d32e3100da8dfce4e28 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D453-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 |
| filingDate | 1993-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9b6bae85819ab1a405c013fe655e3cb8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fdb8d6856f9a9e3cdfabe5c278240b47 |
| publicationDate | 1994-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9414803-A1 |
| titleOfInvention | Quinuclidine derivatives as squalene synthase inhibitors |
| abstract | Compounds of formula (I) in which R1 is hydrogen or hydroxy; R2 is hydrogen; or R?1 and R2¿ are joined together so that CR1-CR2 is a double bond; Ar1 is a phenylene moiety and Ar2 is a heterocyclic moiety; or Ar1 is a heterocyclic moiety and Ar2 is a phenyl moiety; and wherein one or both of Ar?1 and Ar2¿ may optionally bear one or more substituents independently selected from halogeno, hydroxy, amino, nitro, cyano, carboxy, carbamoyl, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, (1-6C)alkoxy, (1-6C)alkylamino, di-[(1-6C)alkyl]amino N-(1-6C)alkylcarbamoyl, di-N,N-[(1-6C)alkyl]carbamoyl, (1-6C)alkoxycarbonyl, (1-6C)alkylthio, (1-6C)alkylsulphinyl, (1-6C)alkylsulphonyl, halogeno (1-6C)alkyl, (1-6C)alkanoylamino, ureido, N'-(1-6C)alkylureido, (1-6C)alkanoyl and oxime derivatives thereof and O-(1-6C)alkyl ethers of said oxime derivatives; provided that Ar2 is not a 6-membered heteroaryl moiety containing one or two nitrogen atoms; when Ar?1 and Ar2¿ are both hydrogen, Ar2 is not an oxadiazole moiety; and their pharmaceutically acceptable salts are inhibitors of squalene synthase and hence useful in treating medical conditions in which a lowering of cholesterol is beneficial. Processes preparing these derivatives, pharmaceutical compositions containing them are also described together with their use in medicine. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7049304-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5494918-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9725043-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6858592-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7456156-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5750538-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7041280-B2 |
| priorityDate | 1992-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 375.