| abstract |
Compounds of formula (I), wherein R1 represents halogen, C¿1-4?alkyl, C1-4alkoxy, hydroxy, NO2, -NR?4R5, R4R5¿NCO(CH¿2?)m-, R?4R5NSO¿2(CH2)m-, R6CONH(CH¿2?)-m or R?7SO¿2NH(CH2)m-; R?4 and R5¿ each independently hydrogen or C¿1-4?alkyl or NR?4R?5¿ represents a 5- to 7-membered heterocyclic ring; R6 represents hydrogen or C¿1-4?alkyl; R?7¿ represents C¿1-4?alkyl; m is zero, 1 or 2; n is zero or 1 to 5; R?2 and R3¿ each independently represent hydrogen, C¿1-6?alkyl or benzyl or -NR?2R3¿ represents a pyrrolidino, piperidino or hexahydroazepino ring; and A represents a bond, a C¿1-5?alkylene chain or a C3-5alkenyle chain wherein the double bond is not adjacent the nitrogen atom; and salts thereof have affinity for the 5-HT1-like receptor and are useful e.g. in the treatment of migraine. |