| abstract |
The invention relates to the novel cyclohexylsulfonyl-acrylic acid and its derivatives of general formula (I), pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them and a process for their preparation. In general formula (I), R means: a hydroxyl group; a phenyloxy group optionally substituted by a C1-4 alkoxy group or halogen; 4-(C1-4 alkoxy)carbonyl-1-piperazinyl group; 4-[(C1-4alkyl)carbonyl-phenyl]-1-piperazinyl group; 4-piperonyl-1-piperazinyl group; 2-[(C1-4 alkoxy)carbonyl]ethylamino group; 1-ethyl-2-pyrrolidinyl-aminomethyl group; or 2-benzyloxy-carbonyl-1-pyrrolidinyl group derived from L-proline. The compounds of general formula (I) possess excellent antiulcer properties and a significant effect against Helicobacter pylori bacteria. Thus, they are useful for the therapeutic and/or prophylactic treatment of various ulcers of the oesophagus, stomach and duodenum. |