http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9414472-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9a4f10fdf67434ec090d32b3b6ece953 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cabed1307939a6fe8a5944f77219b232 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2402 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01051 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y302-01018 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 1993-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d7d89b67d42be674e330c9ed2a92a94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d8c7dd16db44c9dc6f943098db16252 |
| publicationDate | 1994-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9414472-A1 |
| titleOfInvention | Method for inhibition of cell adhesion to receptors containing selectins |
| abstract | A method for inhibition of adhesion of cells to receptors containing selectins in mammals is disclosed whereby an anti-adhesion enzyme is administered to the mammal in a therapeutically effective dosage. In a preferred embodiment, the anti-adhesion enzyme will be administered to treat a chronic or acute inflammatory condition (preferably the latter). In this context, the therapeutically effective dosage will be a dosage sufficient to achieve detectable reduction of the inflammation without substantial toxicity. The enzyme administered will specifically cleave carbohydrate residues which are involved in forming bonds between carbohydrate residues in ligands (typically on leukocytes) which are specific for selectin-containing receptors (typically on endothelial cells), inparticular, bonds formed by fucosylated and/or sialilated residues. The enzyme will preferably be a fucosidase or sialidase and is preferably used in recombinant form. Means are also described whereby the activity of the enzyme can be enhanced to perform optimally at pH 7-7.4 (i.e., the pH of plasma). The enzyme may also be modified to extend its in vivo half-life and shelf life. It is expected that the same enzyme will cleave many adhesion residues. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2141237-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7642395-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7332179-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0063351-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-754480-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0063351-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6774210-B1 |
| priorityDate | 1992-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.