| abstract |
By carrying out the conjugation reaction of an antiviral phosphorylated nucleoside, particularly arabinoside adenine monophosphate, in form of an imidazolide, with lactosaminated human albumin at a pH higher than 7.5, molar ratios drug/L-HSA at least equal to those using ECDI without the problems and negative side effect observed in these latter are obtained. Preferably, the conjugation reaction is carried out at a temperature of 37 °C and a pH of 8.5-9.5. |