| abstract |
The invention provides a polynucleotide in substantially isolated form which comprises a contiguous sequence of nucleotides which is capable of selectively hybridizing to Seq. ID No. 1 or to the complement of Seq. ID No. 1, and a polypeptide in substantially isolated form which comprises: (a) the protein of Seq. ID No. 2; or (b) an allelic variant or species homologue thereof; or c) a protein at least 70 % homologous to (a); or (d) a fragment of any one of (a) to (c) capable of forming a complex with the E2F-1 protein or related family member; or (e) a fragment of any one of (a) to (c) of at least 15 amino acids. |