abstract |
Compounds of formula (I) and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof: X-CO-Y-Z, wherein X is a monocyclic or polycyclic aromatic group, Y is O or NH; Z is of sub-formula (II), wherein -(CH2)n1 is attached at carbon; and n1 is 0, 1, 2, 3 or 4; q is 0, 1, 2 or 3; R¿a? is straight or branched chain alkylene of chain length 1-6 carbon atoms terminally substituted by R7 wherein R7 is aryl, 3 to 8 membered cycloalkyl, 3 to 8 membered heterocyclyl, 5 or 6 membered monocyclic heteroaryl or 9 or 10 membered fused bicyclic heteroaryl linked through carbon, or R7 is C2-7 alkoxycarbonyl or secondary or tertiary hydroxy substituted C1-6 alkyl; and R6 is hydrogen or C1-6 alkyl; or a compound of formula (I) wherein the CO-Y linkage is replaced by a heterocyclic bioisostere; and their use as pharmaceuticals in the treatment of gastrointestinal disorders, cardiovascular disorders and CNS disorders. |