| abstract |
The present invention relates to nucleotide sequences of the human transducin-like Enhancer of split ('TLE') genes, and amino acid sequences of their encoded TLE proteins. The invention further relates to fragments and other derivatives, and analogs, of human TLE proteins, as well as antibodies thereto. Nucleic acids encoding such fragments or derivatives are also within the scope of the invention. Production of the foregoing proteins and derivatives, e.g., by recombinant methods, is provided. Binding partners of TLE proteins are also provided. In particular, the invention provides sequences of four distinct human homologs of the Drosophila TLE gene, and sequences of their unique encoded TLE proteins. In specific embodiments, the invention relates to derivatives and analogs of the human TLE proteins which are functionally active, or which comprise one or more domains of a human TLE protein, including but not limited to the 'Q domain', 'GP domain', 'CcN domain', 'SP domain', 'WD-40 domain', or a WD-40 repeat, casein kinase II (CK II) site, cdc2 kinase (cdc2) site, or nuclear localization sequence motif, consensus sequences for any of the foregoing, or any combination of the foregoing. |