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filingDate 1993-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1994-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-9407888-A1
titleOfInvention Chiral compounds and their use
abstract 4-Hydroxy-δ-lactones are useful intermediates in the preparation of inhibitors of the enzyme (HMG-CoA reductase) that is rate-limiting in cholesterol biosynthesis. They are prepared from synthons of the formula (A) wherein either Y is H and -^_-^_-^_ is a double bond or epoxide, or Y is optionally-blocked OH (above the ring, opposite to Z) and -^_-^_-^_ is a single bond; and Z is an organic group.
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