| abstract |
A condensed thiazole derivative useful as a 5-HT3 receptor agonist, represented by general formula (I), a pharmaceutically acceptable salt thereof, a process for producing the same, and a pharmaceutical composition containing the same, wherein R represents hydrogen, halogen, hydroxy, lower alkoxy, carboxy, lower alkoxycarbonyl, nitro, amino, cyano or protected hydroxy; A represents a benzene or naphthalene ring; one of L1 and L2 represents a mere bond while the other then represents: (a) linear or branched lower alkylene which may be interrupted by oxygen or sulfur, (b) oxygen or sulfur, or (c) lower alkenylene; L represents a mere bond, or linear or branched lower alkylene; Im represents α or β; R?1, R2 and R3¿ may be the same or different from one another and each represents hydrogen or lower alkyl; and R?4, R5 and R6¿ may be the same or different from one another and each represents hydrogen or lower alkyl. |