| abstract |
Compounds are disclosed which display cytotoxic effects against estrogen-independent tumors. These compounds may be represented by the formula X-R1 wherein X is a phenyl ring which may be substituted with one or more nitro, methyl or trihalomethyl groups and R1 is a benzophenone hydrazone, a xanthone hydrazone, a thioxanthone hydrazone, a fluoren hydrazone, an anthraquinone hydrazone, an anthraquinone phenylhydrazone, an indano [1,2,3-de]-2H-phtalazinone, a tetralin [1,2,3-de]-2H-phtalazinone, an acridone hydrazone, or a dibenzosuberenone hydrazone. The R1 moiety may be substituted with one or more hydroxy, methoxy or halogen groups. These compounds are useful as chemotherapeutic antineoplastic agents. |