| abstract |
Tricyclic compounds which inhibit the enzyme thymidylate synthase ('TS'), processes for preparing these compounds, pharmaceutical compositions containing these compounds, and the use of these compounds to inhibit TS, including all effects derived from the inhibition of TS. Effects derived from the inhibition of TS include the inhibition of the growth and proliferation of the cells of higher organisms and of microorganisms, such as yeasts, bacteria, and fungi. Such effects include antitumor activity. |