| abstract |
Compounds of formula (I), and salts and prodrugs thereof, wherein R1 represents H, optionally substituted C¿1-6?alkyl or C3-7cycloalkyl; R?2 is NHR12¿ or (CH¿2)sR?13 where s is 0, 1 or 2; R3 represents C¿1-6?alkyl, halo or NR?6R7; R4 and R5¿ are H , C¿1-12?alkyl optionally substituted by NR?9R9'¿ or an azacyclic or azabicyclic group, optionally substituted C¿4-9?cycloalkyl, C4-9cycloalkylC1-4alkyl, aryl, arylC1-6alkyl or azacyclic or azabicyclic groups, or R?4 and R5¿ together form the residue of an optionally substituted azacyclic or azabicyclic ring system; x is 0, 1, 2 or 3; R12 is optionally substituted phenyl or pyridyl; R13 represents a group (A) wherein R14 is H or C¿1-6?alkyl; R?15¿ is H, C¿1-6?alkyl, halo or NR?6R7¿; and the dotted line is an optional covalent bond; are CCK and/or gastrin antagonists useful in therapy. |