| abstract |
An antihypertensive dihydropyridine compound of formula (1) characterised in that one of W or R1 represents a halo (lower) alkyl group (especially CF¿3?); the other of W or R?1¿ represents a lower alkyl group; R2 represents a lower alkyl group; R3 represents a hydrogen atom or a lower alkyl group; Ar2 represents an optionally substituted aryl group; A represents a cyclo(lower)alkylene group, a lower or higher alkylene group optionally interrupted by a member selected from the group consisting of oxa, imino, substituted imino, a heterocyclic group, a vinylene group, a phenylene group, an -0-phenylene-group, a phenylene-0-group, an -0-phenylene-0-group (the phenylene group in each of which may contain a lower alkoxy substituent) and a group of the formula: -Het-Q- (wherein Het is a bivalent heterocyclic group, and Q is a lower alkylene group); B represents a direct link or -CH¿2?O-; Ar?1¿ represents a pyridyl group or a phenyl group of formula (2) wherein X and Y, which may be the same or different, each represents a hydrogen atom, a halogen atom, a halo(lower)alkyl group, a lower alkoxy group which may contain an amino substituent, or a nitro group, and acid addition salts thereof. |