| abstract |
Various novel phosphono derivatives (XII) of amino acid esters such as the 'nonphenyl-type' N-phosphono compounds of formula (IX): R6-CH[NR7-PO(OR4)(OR5)]COOR3, the 'phenyl-type' N-phosphono compounds of formula (X): R8-CH[NR9-PO(OR4)(OR5)]COOR3, and the 'phenylethylene-type' N-phosphono compounds of formula (XI): R10-CH[NR11-PO(OR4)(OR5)]COOR3 are disclosed as being useful as antiinflammatory and antiarthritic agents. Further disclosed is a method of treating inflammatory and arthritic disease with known N-phosphono derivatives of amino acid esters, the 'benzyl-type' N-phosphono compounds of formula (III): R1-CH[NR2-PO(OR4)(OR5)]COOR3. Additionally disclosed are N,N'-diphosphonodiamine esters of formula (XV) and phosphonophosphinate esters of formula (XVIII): R14-X-(CW)m1-CR15R16-CH2-CM[P(O)(OR4)(OR5)][P(O)(OR4)(R19)] also useful for treating inflammatory and arthritic diseases. |