http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9400115-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_375f3f3cc5ead6395793ac0b057b8889 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d8bfb94a29f3c1a57ad40e8e98f9a20a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-80 |
| filingDate | 1992-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_559955420d1c388892ad96316450433c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_263622d9dd7e999badba2f53ea7fefec |
| publicationDate | 1994-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9400115-A1 |
| titleOfInvention | Bis-(substituted-phenyl) derivatives with cytotoxic and anticancer activity |
| abstract | The invention relates to novel polybenzamide mustards having anticancer and hypoxia-selective properties, to methods of preparing the novel compounds, and to the use of these compounds as anticancer agents. The compounds have general formula (I), wherein M and M1 separately represent H, aziridinyl, N(Et)CH2CH2Y or N(CH2CH2Y)2, where Y is Cl, Br, I or OSO2Me; R and R1 separately represent up to three of H, NO2, aza (ring CH= replaced by N=), CH2Q, SO2NHQ or CONHQ, where Q is H, Me, (CH2)nNMe2, (CH2)nNHC(=NH)NH2 and n = 2-4); X represents CONH, NHCO, O, CH2, NH or S; and A is (CH2)n, where n = 2 to 4, or a unit chosen from formulae (IIa to IIc) wherein Z = CH2Q, SO2NHQ or CONHQ, where Q is H, Me, (CH2)nNMe2, (CH2)nNHC(=NH)NH2 and n = 2 to 4), or an acid addition salt or N-oxide thereof. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011154846-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102933560-A |
| priorityDate | 1992-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 131.