| abstract |
The invention relates to a protein or a peptide containing or constituted by a peptide derived from peptide 18A and presenting the following characteristics: it is coiled in the form of an alpha helix having 5 turns, each turn bearing 3.6 amino acid residues; the diameter of said helix is from about 13 Å to about 16 Å; the distance separating two consecutive turns of said helix being from about 4 Å to about 6 Å; the length of the helix being from about 10 Å to about 30 Å; it is amphipathic; with said peptide being such that: either the amino acid in position 4 is Glu or Asp, and/or the amino acid in position 6 is Glu or Asp, and/or the amino acid in position 8 is Lys or Arg, and/or the amino acid in position 11 is Glu or Asp. This protein can form complexes with phospholipids, with said complexes being useful for the treatment of cardiovascular diseases. |