| abstract |
Compounds having formula (I) wherein Het is ArR1R2R3, Ar is a bicyclic aromatic 8- to 10-membered ring containing 1 to 3 N atoms, the tetrahydro derivatives thereof, and the N-oxides thereof, are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine. |