| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf3a308ab5bd5d267a0914318d61ae36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d5c670c2d30eb817a3d14dae0583441
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec2cf2772a722c89d7cdeaf3f7f441cc |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
1993-05-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e82fbb3b7079d1415814da9a7d27f23c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61aa13fd629e3bbe26137fa0793671dd |
| publicationDate |
1993-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9324653-A1 |
| titleOfInvention |
Antisense oligonucleotides with antitumoral activity, pharmaceutical compositions which comprise them, and their uses |
| abstract |
The present invention relates to antisense oligonucleotides (aODN) which comprise nucleotidic sequences characterized by the possibility of hybridizing, also inside the interior of human cells, to regions of genetic code molecules originated from the translocation of a portion of chromosome 18 to other chromosomes, in particular chromosome 14. Chromosomal translocation is the cause of a large number of diseases, in particular tumors. The inhibition of the biological effects of translocations by antisense oligonucleotides is meaningful from the scientific knowledge, diagnostic and therapeutical viewpoints. The invention relates to the use of such antisense oligonucleotides in order to study the diagnostics and therapy of tumors originated from chromosomal translocation t(14; 18) and the chemical and pharmaceutical modification suitable for rendering them suitable for being administered to human subjects. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7285288-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7704962-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9856905-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9612017-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2311132-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6005095-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2311132-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9627664-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9627663-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9627664-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6291668-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9627663-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6977244-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6140492-A |
| priorityDate |
1992-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |