| abstract |
Novel podophyllotoxin compounds and their use in treating tumors are disclosed. In one embodiment, the compounds have general formula (I), wherein NHR is selected from the group consisting of: (a) NH-(CH2)n-NR1R2, where n=2-4, and where (1) R1 and R2 are the same or different and are H or lower alkyl groups, or (2) NR1R2 is (a1), (a2), (a3), or (a4); (b) where R3 is CH2Ph or CO2Et; and (c) including physiologically acceptable ammonium salts of (a), (b) and (c). |