| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8c0982b0f02b1ed6d20a315370a3a3a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-485
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6878
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-445
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-485
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-445 |
| filingDate |
1993-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1535c003a6d7430bc75f78861713335
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a41af87ef9e796093381735be034667
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d233f7d81a5ba44d8576f1f09c87aef
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab52789bcd6bb94b3bad6a999ee3893f |
| publicationDate |
1993-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9321206-A1 |
| titleOfInvention |
Synthetic, stabilized, three-dimension polypeptides |
| abstract |
Methods for synthesizing three-dimensional stabilized peptides which mimic the three-dimensional configuration of the active site of a natural, biologically active protein are carried out by (1) noting the three-dimensional configuration of the active site of a known biologically active protein, (2) noting the amino acid sequence and the hydrogen bonds existing between amino acids which hydrogen bonds are capable of maintaining the three-dimensional configuration of the active site and (3) producing a synthetic three-dimensional peptide to mimic the structure of the active site. The synthetic peptide is synthesized so as to have the same or a similar amino acid sequence to the amino acid sequence of the active site of the biologically active polypeptide but with the stabilizing hydrogen bonds being replaced by a bridging divalent radical selected from the group consisting of -(N)-C(CH3)=N(H+)-CH2-(N)-; -(N)-C(CH3)=N(H+)-CH2-CH2-(N)-; and -(N)-N=CH-CH2-CH2-CH2-(C)-. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6274556-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1394180-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6037324-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0004380-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109111371-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109111371-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004014951-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004014951-A3 |
| priorityDate |
1992-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |