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filingDate 1993-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1993-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-9319773-A1
titleOfInvention Lyophilized somatotropin formulations
abstract Somatotropin solutions which remain clear for extended periods and which remain clear when subjected to mechanical agitation are prepared by mixing a lyophilized somatotropin composition containing about 1 part somatotropin per 2 to 8 parts arginine HC1 on a weight basis, wherein the pH of the composition prior to lyophilization was about 7.2 to about 8.5, and a biocompatible diluent which comprises EDTA and a nonionic surfactant. If the pH of the somatotropin composition prior to lyophilization was between 7.2 and 7.8, the diluent further comprises a buffer; otherwise the diluent optionally further can comprise a buffer or nonbuffering agent.
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priorityDate 1992-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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