| abstract |
Compounds useful in inhibiting the biosynthesis of leukotrienes have structure (I), where M is hydrogen, a pharmaceutically acceptable cation, or a metabolically cleavable group, R4 is alkyl, cycloalkyl or -NR5R6, where R?5 and R6¿ are hydrogen, alkyl, cycloalkyl or alkanoyl, where A is a valence bond or is a straight or branched divalent alkylene group of from one to twelve carbon atoms, R?2 and R3¿ are independently selected from hydrogen, straight or branched alkyl of from one to twelve carbon atoms, halogen, or trifluoroalkyl, and R1 is selected from phenoxy, phenylthio, 2-, 3-, or 4-pyridyloxy, 1-, or 2-naphthyloxy, or 2-, 4-, 5-, or 8-quinolyloxy, all optionally substituted with alkyl, haloalkyl, alkoxy, hydroxy or halogen. |