| abstract |
Sulfonic acid stilbenes of formula (I) wherein B is -CH=CH- (cis or trans), -CH2CH2- or a bond; X is NH or oxygen; Y is oxygen or sulfur; Z is NH, CH2, oxygen or sulfur; R1 is hydrogen, C1-C4 alkyl, -CH2-Ar, or -Ar wherein Ar is a phenyl or naphthyl group, the phenyl or naphthyl groups optionally substituted by a C1-C4 alkyl or SO3M3 group; and M1, M2, and M3 are each independently a hydrogen or a pharmaceutically acceptable cation sulfonic acid stilbenes block the infection of cells by HSV, HIV and CMV and these compounds can be used to prevent viral infection. |