| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5ddced4c203e56346f054e364b141ba |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-193
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1841
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4702
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-22 |
| filingDate |
1993-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_177bd3ae2e332f6de7a03723969b51e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77379b933ef33e129f6f0b4e47ed4c09 |
| publicationDate |
1993-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9314782-A1 |
| titleOfInvention |
Methods of controlling the proliferation of macrophages |
| abstract |
This invention provides a method for stimulating or inhibiting the proliferation of differentiated macrophages by modulating the amount or activity of TGF-β in contact with said differentiated macrophages, as by contact with an effective amount of M-CSF or GM-CSF and TGF-β. The invention further provides a method for treating an individual with a condition characterized by the overabundance or lack of adequate differentiated macrophages by modulating the amount or activity of TGF-β activity in macrophage-containing tissues of said individual, as by administering an effective amount of M-CSF or GM-CSF and TGF-β, or by contacting differentiated macrophages with an agent, such as an antibody or decorin, which suppresses the activity of TGF-β. Further, the invention provides methods for stimulating proliferation of immature macrophages by contact with TGF-β. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9921542-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7368111-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8008353-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7087648-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9921542-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8198334-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7151169-B2 |
| priorityDate |
1992-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |