| abstract |
A heme polymerase is described. The polymerase is critical in the biology of malaria. By using this novel polymerase, assays useful in developing anti-malaria drugs are made possible. Beyond providing a key for future drug studies and biochemical characterizations, treatments for malaria including quinoline-resistant malarias are made possible. Further, by employing polymerase-inhibiting techniques, such as polymerase inactivation or by offering an alternative substrate, significant breakthrough malaria treatment, prophylaxis and research are made possible. |