Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a5e95156255d5fe8b2923c544786e176 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-82 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-32 |
filingDate |
1992-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38c12198096bc9c12abafdcfed95f094 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acfee31378825393e5440bb9eab3b9b9 |
publicationDate |
1993-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-9312136-A1 |
titleOfInvention |
Detection and treatment of acute leukemias resulting from chromosome abnormalities in the all-1 region |
abstract |
Methods are provided for the diagnosis and treatment of human leukemias involving breakpoints on chromosome 11 in the ALL-1 locus. The ALL-1 breakpoint region, an approximately 8 kb region on chromosome 11, illustrated in the figure, is disclosed. The ALL-1 region is involved in translocation in acute lymphocytic, myelomonocytic, monocytic and myelogenous leukemias. Probes which identify chromosome aberrations involving the ALL-1 breakpoint region on chromosome 11 are also provided. The cDNA sequence of ALL-1 gene on chromosome 11 is provided. A partial sequence of the AF-4 gene is also provided in the context of the sequences of two reciprocal endproducts of a translocation. Amino acid sequences corresponding to the cDNA sequences of the entire ALL-1 gene and the partial sequence of the AF-4 gene are also provided. Probes are provided for detecting chromosome abnormalities involving the ALL-1 gene on chromosome 11. Monoclonal antibodies for diagnosis and treatment and antisense oligonucleotides for treatment of acute leukemias are also described. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8916533-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9854319-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8911998-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6040140-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9824928-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9125923-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5487970-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5567586-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8859202-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8946187-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9824928-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9708339-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9481885-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11679157-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9249468-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10758619-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9434995-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9085804-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0668765-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0668765-A4 |
priorityDate |
1991-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |