http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9310135-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61f88efcda59d7062a4252ecf6886f58 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-002 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 |
| filingDate | 1992-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2a0f860a54f2fa83cb0d736f021c6dc |
| publicationDate | 1993-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9310135-A1 |
| titleOfInvention | Characterization of estrogen responsive mouse lactoferrin promoter |
| abstract | The promoter region of the mouse lactoferrin gene was cloned and sequenced. Several clones containing lactoferrin gene fragments were isolated from a mouse (129/J) genomic library including clone μJ14 which contains 7.5 kbp 5'-flanking sequence. Sequence analysis of the region flanking the transcription initiation site revealed the following: a TATA like sequence, two CAAT boxes, three GC boxes including one within the first intron, an AP2 site, seven PU boxes, an AC rich region, a B1 sequence and an estrogen responsive element (ERE) consensus sequence overlapping with a COUP binding element. Footprinting analysis demonstrated that several regions, including the putative ERE region, in the 5'-flanking sequence were protected from DNase I digestion. Promoter fragments were cloned into a chloramphenicol acetyltransferase reporter-plasmid to study functional activity. The mouse lactoferrin gene promoter was active in human endometrium carcinoma RL 95-2 cells and in rat glioma C6 cells. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9606938-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5830880-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-696593-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9606940-A1 |
| priorityDate | 1991-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.