| abstract |
The present invention relates to compounds of formula (I), and the pharmaceutically acceptable salts thereof, wherein Z can be (a) wherein R3 is alkyl having 1 to 6 carbon atoms and, when n is greater than 1, each R3 can be the same or different; and n is an integer from 1 to 3; or (b); R?1 and R2¿ can each independently be hydrogen, straight or branched chain alkyl, or cycloalkyl having 3 to 8 carbon atoms which can optionally be substituted at one or more positions by alkyl of 1 to 6 carbon atoms; X is oxygen, sulfur, NR4, wherein R4 is hydrogen or alkyl having 1 to 4 carbon atoms, C=O, CHOH, or CH¿2?; Y is hydrogen, alkoxy, halogen, alkyl, or hydroxy; and m is an integer from 0 to 3. The compounds are antagonists of platelet-activating factor (PAF). |