| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_11051970f997db1d4a6e136a87739659 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5078
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-55 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-28 |
| filingDate |
1992-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3dd9c713c34c5f883b93f2a530b28579
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ebb8f29473fc2e20fd4597ee6d7706b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3d52188e151b3f41ebad4476ccdb475d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4def6da7a811aa9e59fc9f347ad4dc77 |
| publicationDate |
1993-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9309767-A1 |
| titleOfInvention |
Prolonged release diltiazem-based formulation |
| abstract |
Prolonged release diltiazem-based formulation for oral administration comprising an organic acid-free microgranule capable of having an irritating effect. Said microgranule comprises: a) a central inactive spherical particle; b) a plurality of alternating primary and secondary layers surrounding the spherical particle, thereby forming a core, and c) an outer coating comprising initial membranous inner layers applied to said core, and a single outer membrane forming a relatively thick and even layer surrounding said initial membranous inner layers; the number of layers of the first inner membrane and the thickness of the single outer membrane being chosen so that diltiazem is released from the microgranule at a speed ensuring the latter's controlled absorption during a period of twenty four hours following oral administration. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2742660-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6383516-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6228395-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0141744-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9816206-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9723219-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5914132-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6660296-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014104840-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6214385-B1 |
| priorityDate |
1991-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |