| abstract |
A methanediphosphonic acid derivative represented by formulae (I) or (II), a process for producting the same, and a medicinal use thereof, wherein B represents hydrogen, alkyl, hydroxy, alkoxy or amino; D represents sulfur, oxygen, NH, alkyl-substituted nitrogen, CH2 or SCH2; X represents alkyl which may be substituted by a heteroatom, aryl or acyl; m represents an integer of 1 to 5; and R?1, R2, R3 and R4¿ represent each independently hydrogen, C¿1? to C7, alkyl or a pharmacologically acceptable cation. The compound is excellent in IL-1 inhibition, antioxidant activity and bone resorption inhibition and useful for treating inflammation, rheumatism, bone metabolism disorder, autoimmune disease, osteoporosis, and so forth. |