abstract |
The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by formula (I), wherein R, R', R1?, R'1?, R2?, R'2?, R3?, R'3?, R4?, R'4?, R5?, R'5?, R6?, R'6?, R7?, R'7?, R8?, R'8?, R9? and R'9? and X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, hypertension and all other conditions of oxidant-induced tissue damage or injury. |