| abstract |
An artificial blood substitute comprising Lewis acid - Lewis base salt film microcapsule having a perfluorocarbons encapsulated therein. The Lewis base may be a polyoxyalkylene adduct of an amine, having structure (I) in which, independently, R1=(II), a=7-26, R2=-CH2-O-R1 or CH2-N-(R1)2, R3=(III), b=7-26, and R4=H, CH3 or alkyl, and said Lewis acid may be a polyoxyalkylene derivative of a polymeric acid having structure (IV), in which c- and d-type repeat units are randomly distributed within the polymer, c=70 to 3150, c-type repeat units comprise from 50-90 % of the total polymer, d=70-1750, the sum of c+d is in the range from about 140 to about 3500 and in which R=(V), where R' and R'' independently = H or CH3 and e=7-75, f=7-75, and the sum of e+f=14 to 85. |