| abstract |
Compounds of formula (I) and salts and prodrugs thereof wherein, Q is optionally substituted phenyl, heteroaryl or naphthyl; X and Y are each H, C1-6 alkyl, C2-6 alkenyl or X and Y are together =O; Z is O or S; R1 is H, optionally substituted C¿1-6? alkyl, optionally substituted phenyl(C1-4 alkyl), C2-6 alkylene, COC1-6 alkylhalo, COR?a, COORa, CONHRa¿, COC¿1-6?alkylNR?aRb¿ or CONRaC1-6alkylCONRaRb; R2 is substituted C¿1-6? alkyl, optionally substituted phenyl(C1-4 alkyl), C2-6 alkylene, C1-6alkylhalo, COR?a, COORa, CONHRa¿, COC¿1-6?alkylNR?aRb¿ or CONRaC1-6alkylCONR?aRb; or R1 and R2¿ together form a chain (CH¿2?)p optionally substituted by oxo; R?3¿ is H or C¿1-6? alkyl; R?4¿ is H, C¿1-6? alkyl or phenyl; and R?5¿ is optionally substituted (CH¿2?)qphenyl; are tachykinin antagonists useful for treating pain. |