| abstract |
The present invention relates to a method for the preparation of a heterologous protein of interest in mature form or fused in the milk of a mammelian female, method wherein: said female is bred and the milk is collected and said protein is recovered from the milk and separated if necessary, the method being characterized in that said female is a transgenic animal in the genome of which has been integrated a sequence coding for said protein of interest under the control of at least one sequence present amongst the elements of expression of the rabbit WAP protein and situated on the fragment having a length of at least 3 Kb from the extremity 3' of the complete WAP promoter. The invention also relates to the milk product obtained and to a eukaryotic cell having the integrated sequences disclosed. |