http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9220688-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-18 |
| filingDate | 1992-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_409c19b25b481028306447cd97a0d225 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a2f3d8cfb9829b01683d207bf358091 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a56cd250a316a33ab7ad6f1123ef5af2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e308c3804a3f02ad1268aa221d07e5d |
| publicationDate | 1992-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-9220688-A1 |
| titleOfInvention | Amino o-aryl, o-alkyl, o-alkenyl and o-alkynyl macrolides |
| abstract | Amino O-aryl, O-alkyl, O-alkenyl and O-alkynyl macrolides of general structural formula (I) have been prepared from suitable precursors by arylation or alkylation and amination at C-3''/C-4'' of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants. In addition, these macrolide immunosuppressants are useful in the topical treatment of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses. Also, these macrolides are useful in the treatment of reversible obstructive airways disease, particularly asthma; as hair revitalizing agents, especially in the treatment of male pattern alopecia or alopecia senilis; in the reversal of multidrug resistance of tumor cells; in treatment of inflammation of mucosa and blood vessels, gastric ulcers, vascular damage, ischemic bowel disease, inflammatory bowel disease, necrotizing enterocolitis, intestinal lesions associated with thermal burns; in the treatment of cytomegalovirus infection; and in the treatment of idiopathic thrombocytopenic purpura and Basedow's disease. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5310901-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5310903-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5258389-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0766685-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5599927-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5563172-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5530120-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0766685-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5530119-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5541193-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9504061-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2583678-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9535299-A1 |
| priorityDate | 1991-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 612.