| abstract |
A triphenylalkene derivative represented by general formula (1), a pharmaceutically acceptable acid addition salt thereof, and a pharmaceutical composition thereof having a tumor inhibitory action and an osteoporosis curing activity. In general formula (1) R1? represents a group selected among those represented by formulae (2), (3) and (4); R6? and R7? represent each hydrogen, alkyl or cycloalkyl, or R6? and R7? together form a heterocyclic group with the adjacent nitrogen atom, provided that R6? and R7? should not be hydrogen atoms at the same time; R8? represents hydrogen or alkylcarbonyl; R2? represents alkyl or cycloalkyl; R3? represents phenyl or 3,4-methylenedioxyphenyl, provided that when R3? represents phenyl, the case where R1? represents a group of formula (4) is excluded; R4? represents hydrogen, hydroxyl, R9?C(O)O-, R10?OCH2?O-, -OPO(OH)2? or CH=NOR11?; R9? represents alkyl; R10? represents alkyl or alkylcarbonyl; R5? represents hydrogen or CH=NOR11?; and R11? represents hydrogen, alkyl or substituted alkyl. |