| abstract |
Antibacterial compounds having formula (I) and pharmaceutically acceptable salts thereof, wherein R?1 is -NR?4R?6, where R?4 and R?6 are independently selected from the group consisting of hydrogen, loweralkyl and arylalkyl or, together, R?4 and R?6 form a nitrogen-containing heterocycle attached at the nitrogen atom; R?2 is selected from the group consisting of hydrogen, -OH and, when R?3 is methylene, oxygen so as to form an epoxide; and R?3 is selected from the group consisting of -CH2?OH, -NR?4R?6, -(CH2?)n?NR?4R?6 and, when R?2 is oxygen, methylene so as to form an epoxide, where n is 1-4 and R?4 and R?6 are as previously defined, with the proviso that when R?2 is -OH, R?3 may not be -NR?4R?6; or R?2 and R?3 together are =CH2?; also disclosed are processes and intermediates useful in the preparation of the above compounds, as well as compositions containing the same methods for their use. |